When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor ...
LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically containing a gene ...
Loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal ...
Loss of heterozygosity (LOH) is a common form of allelic imbalance by which a heterozygous somatic cell becomes homozygous because one of the two alleles gets ...
由 CA Nichols 著作 · 2020 · 被引用 71 次 — Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor ...
由 GL Ryland 著作 · 2015 · 被引用 160 次 — Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type ...
由 X Zhang 著作 · 2021 · 被引用 34 次 — Loss of heterozygosity (LOH) is a common genetic event in the development of cancer and is known to play an essential role in the somatic loss ...
2023年11月15日 — Loss of heterozygosity is a type of genetic mutation common in many cancerous cells. Learn more about what happens when this gene cannot ...